Medicinal Chemistry Programmes

DEPARTMENT OF PHARMACEUTICAL AND MEDICINAL CHEMISTRY

A)  FULL-TIME BACHELOR OF PHARMACY (B.PHARM) PROGRAMME.

Admission Requirements

Regular undergraduate students are admitted into the programme through University Matriculation Examination (UME), Direct Entry and JUPEB

Minimum of five (5) O’ LEVEL credits to include: English Language, Mathematics, Physics, Chemistry, Biology obtained in not more than two sittings.

B)MASTERS’ DEGREE

  1. MASTER OF PHARMACY DEGREE (M. Pharm)

The candidate must have a first degree with a FCGPA of not less than 3.0 in Pharmacy from Nnamdi Azikiwe University or a recognized University.

 

     2.MASTER OF SCIENCE (M. Sc)

The candidate must have a first degree with a FCGPA of not less than 3.0 in Chemistry or Biochemistry from Nnamdi Azikiwe University or a recognized University.

C)DOCTOR OF PHILOSOPHY (Ph.D) DEGREE

A candidate who holds a master’s degree in Pharmaceutical/Medicinal Chemistry, Pharmacognosy (Pharmaceutical Biology), Chemistry or Biochemistry with a FCGPA of not less than 3.50 on 5.0 scale or an average of 70 % from Nnamdi Azikiwe University or a recognized University may be admitted provided the University Matriculation requirement is satisfied.

AVAILABLE AREAS OF SPECIALIZATION

  • Drug synthesis and Combinatorial Chemistry
  • Medicinal Chemistry and Drug Design
  • Natural Products Medicinal Chemistry
  • Quality control and Analytical Pharmaceutical Chemistry

 

UNDERGRADUATE COURSES

1st Year, First Semester
Course Code Course Title Credits
ICH101 Basic Organic Chemistry 2
ICH111 Basic Inorganic Chemistry 2
BIO101 General Biology 1 2
PHY101 General Physics 1 3
PHY103 General Physics 111 3
PHY107 General Physics Lab 1 1
MAT101 General mathematics 1 3
GSS 101 Use of English 1 1
GSS 105 Humanities 2
GSS107 Nigerian Peoples and Culture 2
GSS108 Basic Igbo Studies 1 1
CSC Introduction to Computer Programming 2

 

1st Year, Second Semester
Course Code Course Title Credits
ICH102 Basic Physical Chemistry 2
ICH112 Basic Practical Chemistry 1
BIO102 General Biology 11 3
BIO103 General Practical Biology 1
PHY102 General Physics 11 3
PHY108 General Physics Lab 11 1
MAT102 General Mathematics 11 3
GSS102 Use of English 11 1
GSS106 Social Sciences 2
GSS109 Basic Igbo Studies 11 1
CSC102 Introduction to Computer Programming 11 2
ZOO102 Introduction to Zoology 2

 

 

2nd Year, First Semester
Course Code Course Title Credits
PCL201 Introduction to Pharmacy Practice 2
PTE203 Pharmaceutical Calculations 2
PMB205 Introduction to Biochemistry 3
PCO211 Human Gross Anatomy/Neuroanatomy 2
PCG221 Introductory Pharmacognosy 2
PCO213 Introduction to Human Physiology 1 2
PCO215 General Principles of Physiology 2
PMC231 General Pharmaceutical & inorganic chemistry 2
PMB281 Introductory Pharmaceutical Microbiology 2
PCO217 Practical Human Anatomy/Histology 1
PMB283 Practical Introductory Pharmaceutical Microbiology 1

 

 

2nd Year, Second Semester
Course Code Course Title Credits
PCO214 Introduction to Human Physiology 11 2
PCG222 Indigenous Medicinal Plants 2
PMC232 General Physical,Organic and Radio Chemistry 3
PTE242 Introduction to pharmaceutics 3
PMB202 Introductory Practical Biochemistry 1
UMT100 University Mandatory Information Technology Training 0
PHM204 Use of Library and Study Skills 1
PCO212 Human Genetic Anatomy/Histology 2
PCG224 Practical Pharmacognosy 1
PMC234 Practical Pharmaceutical Physical Chemistry 1
PTE244 Practical Pharmaceutics (Dispensing) 1
ENT200 Entrepreneurship education and new venture creation 0

 

 

3rd Year, First Semester
Course Code Course Title Credits
PCG321 Natural Products 3
PMC331 Pharmaceutical Organic Chemistry 3
PTE341 Physical Pharmaceutics 3
PCO351 Principles of Pharmacology 2
PCO353 Pharmacology of GIT and Peripheral nervous systems 2
PCL371 Introducti0n to Pharmacy Administration & Management 2
PMB381 Antimicrobial Pharmaceutical Products 2
PCG323 Practical Pharmacognosy 11 1
PTE343 Practical  Physical Pharmaceutics 1
PMB383 Practical Antimicrobial Agents evaluation 1

 

3rd Year, Second Semester
Course Code Course Title Credits
PMC332 Pharmaceutical Specification and Standardization 2
PTE342 Unit Operations 2
PCO352 Pharmacology of Cardiovascular and central nervous system 2
PCL362 Pharmacokinetics and Biopharmaceutics 2
PCL364 Health Psychology 2
PHM306 Biostatistics and Research Methods in Pharmacy 3
PMB382 Sterile Products Technology 3
PMC334 Practical Pharm. Qualitative Analysis 1
PCO354 Practical Pharmacology 1 1
PTE344 Practical Unit Operations & Dispense Systems 1
PMB384 Practical Sterile Products Technology 1
ENT300 Entrepreneurial Skills 0

 

4th Year, First Semester
Course Code Course Title Credits
PCG421 Phytoevaluation and phytoanalysis 2
PTE441 Tblet & Capsule Technology 2
PCO451 Chemotherapy 2
PCL461 Pathology for Pharmacy Students 2
PCL471 Pharmacy Ethics & Jurisprudence 3
PMC431 Instrumental Methods in Pharmaceutical Analysis 2
PMB481 Evaluation of antimicrobial agents 2
PMB483 Advanced Practical antimicrobial agents Evaluation 1
PCO453 Practical Pharmacology 11 1
PMC433 Practical Pharmaceutical Analysis 11 1
PMC435 Practical Pharmaceutical Synthesis 1
PTE443 Practical Tablet and Capsule Technology 1

 

4th Year, Second Semester
Course Code Course Title Credits
PMC432 Medicinal Chemistry 3
PMB482 Basic Pharmaceutical Biotechnology and immunology 3
PMB484 Practical Introductory Pharmaceutical Biotechnology 1
PTE444 Advanced Dispensing 2
PCG422 Practical Phytoevaluation and Phytoanalysis 1
PCL462 Introduction to Clinical and Public Health Pharmacy 2
PCO452 Pharmacology of Endocrine and Respiratory Systems 2
PTE446 Practical Advanced Dispensing 1
PCL464 Supply Chain Management of Pharmaceutical and other heallth commodities 3
PHM472 SIWES 4

 

5th Year, First Semester
Course Code Course Title Credits
PCL561 Pathology & Pharmacotherapeutics 3
PCG521 Herbal,Complementary & Alternative Medicines 2
PCO551 Screening Methods in Pharmacology 2
PTE541 Novel Drug Delivery Sysems and Drug Stability 3
PMC531 Pharmaceutical Analysis and Good Laboratory Principles 2
PCO553 Toxicology 2
PMB581 Clinical Applications of Pharmaceutical Microbiology 2
PCL563 Clinical Pharmacokinetics & Clinical Safety Evaluations 2
PCL571 Pharmacy Administration and Management 2

 

 

5th Year, Second Semester
Course Code Course Title Credits
PCL562 Drug information,Literature Evaluation & Communication Skills 2
PCL564 Clinical Pharmacy Clerkship 4
PCL566 Drug Administration & Patient Medical Assessment 2
PMB582 Pharmaceutical Biotechnology 3
PMC532 Medicinal Chemistry,Drug Design and Development 3
PTE542 Industrial Pharmacy and Process Validation 2
PCO552 Veterinary Pharmacy and Agrochemicals 2
PHM592 Research Project 4

 

PG COURSE DISTRIBUTION  

  1. PMC 801 Research Techniques in Pharmaceutical and Medicinal Chemistry
a Literature review of relevant pharmaceutical materials used in the preparations of organic compounds involving various named reactions; isolation and characterization of natural products e.g alkaloids, glycosides, flavonoids, essential oils etc. Dr. Mrs Blessing Umeokoli
b Qualitative estimation of elements in organic compounds and quantitative estimation of various functional groups. Assay of selected drugs by official methods. Dr. F.A Onyegbule
c Experiments on electrophoresis, Chromatography, spectrophotometry, calorimetry and other relevant and current techniques. Dr. K.G Ngwoke
d Proposal writing.

Overview of techniques in molecular visualization and modeling.

Prof. I.C Uzochukwu

 

  1. PMC 803 Advanced medicinal Chemistry
A A general study of the correlation of physical properties and chemical structure with biological activity. Stereochemistry and drug action.

Introduction to nanomedicinal chemistry: gold nanoparticles, carbon nanostructures, organic functionalization of carbon nanostructures and application in biomedicine

Prof. F.B.C Okoye
b Structure – activity relationship and mechanism of action of some important categories of drugs such as : tranquilizers, new steroidal drugs. Dr. K.G Ngwoke
c Chemotherapy of neoplastic diseases, antiviral drugs

A critical review of drugs comprising racemic mixtures

Dr Mrs C.C Abba

 

 

  1. PMC 827: Computational Chemistry and Molecular Modeling
a What is Bioinformatics ? Glossary of terms  Overview of bioinformatics and applications: Drug discovery Chemoinformatics; An important scientific discipline Visualization of biomolecules using VMD, PyMol etc.

History of human genome project and important tropical pathogens such as plasmodium. Students should prepare an updated table of important genome projects. Definition of the ‘omics’, genome annotation, genome association studies. Pharmaceutical significance of bioinformatics. Examples of their application in pharmaceutical science. The hidden markov model, gene annotation, protein structure prediction, sequence analysis and alignment using TCoffe, DaliLite etc, evolutionary and phylogenetic analysis, algorithms in protein analysis. Mathematical modeling of drug design and interactions. Chemical formula file format. ADMET prediction tools. Other Chemoinformatic tools and approaches. Viral screening protocols.

Prof. I.C Uzochukwu
  1. PMC 811: Pharmaceutical Analysis and Quality Control
a The study of chemical basis of product quality control and assurance. A detailed approach to the instrument and chemical analysis of raw materials employed in the production of pharmaceutical and cosmetics. Dr Mrs C.C Abba

 

b The application of available analytical methods in establishing the quality of pharmaceuticals/cosmetics and mixtures thereof, especially of those products marketed in Nigeria. In vivo and in vitro correlation. Review on bioanalytical method validation. EMEA of analytical procedure. Prof. I.C Uzochukwu

 

  1. PMC 823: Advanced Drug Design
a A comprehensive study of the relevant factor in rational drug design. Drug receptor interactions. Drug discovery process. Hit identification, lead discovery. Quantitative structure activity relationships, 3D QSAR. Dr. K.G Ngwoke
b Custom design and synthesis of specific, pure, and desired drug molecules. Enzyme inhibition. Design of prodrugs. The Lipinski rule among other rules to predict drug-likeness. Blood brain barrier permeability etc. Approach and examples of drug repurposing Prof. I.C Uzochukwu

 

  1. Advanced Organic Chemistry
a A detailed study of organic reaction mechanisms. Kinetics, electronic effects, polar free radical and pericyclic mechanisms. Stereochemistry; stereoselective synthesis. Study of important name reactions (including applications in drug synthesis) Prof. P.O Osadebe

 

b Advanced mechanism of nucleophilic substitution reactions and factors affecting them. Elimination reaction; mechanisms and factor affecting them.

Organo-mettalic compounds, Grignard synthesis, organo-aluminium, organo-zink, organo-zink, organo-lithium compounds, preparation and uses.

Some specific organic reactions: Michael addition, Walden inversion, Woodward-Hoffmann-rule. Recent methods for forming Heterocyclic rings, Synthesis using intermediates.

Dr. Mrs Blessing Umeokoli
c Synthetic uses of free radicals: main types of free radicals reaction. Radical forming reactions, radical destroying processes, radical transfer processes. New reduction methods; electrochemical reduction; photochemical reduction. New oxidation methods; electrochemical oxidation, organic peroxide. Photochemical methods; photo addition reactions, photocyclization, rearrangement. Dr. F.A Onyegbule
d Aromatic substitution reactions, new synthesis of aromatic compounds, ring synthesis, synthesis of reactive intermediates, functional groups, some specific organic reactions, 1,3-dipolar cyclo-addition reactions. Diel-adder synthesis. Photochemical ring closures, ring expansion reactions, miscellaneous ring synthesis. Green chemistry concept. Prof. F.B.C Okoye

 

    7. PMC 802: Modern Analytical Techniques

A Principle of spectrophotometry and applications of absorption spectra (ultraviolet, visible, infrared), to structure elucidation and determination in pharmaceutical chemistry.

Atomic absorption spectroscopy, flame photometry, fluorescence.

Dr. Mrs Blessing Umeokoli
B The use of nuclear magnetic resonance (1D and 2D, 1HNMR and 13C NMR), mass spectroscopy in confirmation of organic structures. Prof. F.B.C Okoye

 

C Gas Liquid Chromatography (GLC), High Pressure Liquid Chromatography (HPLC), Hyphenated Techniques. Electrophoresis. Dr. K.G Ngwoke
D Polarimetry: X-ray diffraction analysis. A course of laboratory work in which the students are expected to make use of the following instrumental and chemical methods in analysis and quality control of chemicals and pharmaceuticals. Electrochemistry (mainly potentiometric titration and polarography).

Non aqueous titration; oxygen combusting flask, complexometric titration EDTA. Indicator extraction methods.

Dr. F.A Onyegbule

 

 

    8.PMC 806: Laboratory Instruction Orientations

A This involves participation in the preparation and instruction of undergraduate practical in Pharmaceutical and Medicinal Chemistry Department as a teaching assistant followed by the submission of a written report in the form of log book Departmental PG Coordinator/HOD

 

    9.PMC 812: Toxicological Chemistry

A Qualitative and quantitative analysis of various potent toxic drugs viz: barbiturate, opium, chlordiazepoxide, diazepam Dr Mrs C.C Abba
B Qualitative and quantitative analysis of various potent toxic drugs viz: acontrine, strychnine, methaqualone, glutethimide, deiphenylhydrazine, phenothizines. Dr. F.A Onyegbule

 

C Specific analysis of heavy metals by atomic-absorption spectroscopy viz: arsenic, beryllium, bismuth, copper, iron, lead, lithium, mercury, nickel, tantalum and zinc.

Isolation of toxic compounds and their determination utilizing modern methods of analysis

Dr. K.G Ngwoke

 

 

 

  10.PMC 824: Drug synthesis and Combinatorial Chemistry

A Introduction to combinatorial chemistry and drug synthesis. Case studies of several reactions affording drug molecules. Prof. F.B.C Okoye

 

B The concept of green chemistry. Semi synthesis of drugs using typical examples such as artemisinin. Prof. I.C Uzochukwu

 

    11.PMC 826: Pharmocokinetics

A Kinetics of absorption, distribution and elimination. Drug metabolism, mathematical treatment of the various pharmacokinetic processes; urinary, plasma/serum and salivary pharmacokinetics models. Dr Sunny Nduka

 

    12.PMC 828: Chemistry of Natural Product

A General methods of isolation and purification of plant products. Study of biogenesis; acetate hypothesis, isoprene roles, biogenetic hypothesis relating to alkaloids. Dr. K.G Ngwoke
B The chemistry and biosynthesis of natural products including alkaloids, flavonoids, steroids, terpenoids, tannins, glycosides, lipids, proteins, carbohydrates Dr Mrs C.C Abba
C General study of natural of natural products from microorganisms (including fungi endophyte) and marine organisms.

Application of NMR and mass spectrometry in structure elucidation of plants. Secondary metabolites viz: steroids, terpenes, alkaloids, flavonoid and flavonoid glycosides and other phenolic compounds.

Prof. F.B.C Okoye

 

 

    13.PMC 804: Applied Biostatistics

Biostatical definition: Variance, Standard deviation and Standard error. Normal distribution, Confidence limits.

Meaning and uses of statistics. Frequency distribution, sampling and sampling techniques, questionnaire design, measures of central tendency and measures of dispersion.

 

Probability and probability distribution; Estimation, Point and interval estimation. Test of hypothesis of hypothesis, regression and correlation, Chi-square, null hypothesis, T-Test, Analysis of variance, One way and two way ANOVA, Simple non-parametric tests, Latin square design, Randomized complex block design, Missing data, sub-sampling; Transformation; Analysis of clinical trials; Application; Fertility indicator and positive health indicator and index.

 

Pictorial presentation of data; pie chart, bar chart. Risk assessment, odd ratios etc. Study of various computer packages relevant in solving pharmaceutical and biomedical problems.

Dr Mrs Chinwe Uzuke

 

LIST OF ACADEMIC STAFF 

 

S/N

 

NAME OF STAFF

 

PRESENT RANK

 

ACADEMIC QUALIFICATIONS

 

STAFF ID NO

1. Dr. Abba Chika Christiana Senior Lecturer B.Sc, B.Pharm, M.Pharm

Ph.D

SS- 2731
2. Prof. Osadebe, Patience Ogoamaka Adjunct Professor B.Pharm, M.Pharm, Ph.D SS-2233
3. Prof. Eboka Chukwuenwenive Jonathan Adjunct Professor B.Sc, M.Sc, Ph.D SS-2749
4. Prof.  Uzochukwu Ikemefuna Chijioke Professor B. Pharm, M. Pharm

Ph.D

SS-1766
5 Prof.  Okoye Festus Basden Chiedu Professor B. Pharm, M. Pharm

Ph.D

SS-2509
6. Dr. Onyegbule Ahamefule Felix Reader B.Sc, M.Sc, Ph.D SS-2152
7. Dr. Ngwoke Kenneth Gerald Senior Lecturer B. Pharm, M. Sc, Ph.D SS -2683
8. Pharm Okafor Uche Gabriel Lecturer I B.pharm , M. Pharm SS-1979
9. Dr. Fortunatus C. Ezebuo Lecturer II B.Sc  M.Sc Ph.D SS 4287
10. Anyanwu Ogechi Ozioma Lecturer II B.Sc, M.Sc SS  3725
11. Pharm. Okpoli, Innocent Nchekwube Lecturer II B.Pharm, M.Pharm
12. Pharm. Okolo, Chukwubuikem Chinaeze Lecturer II B.Pharm, M.Pharm
13 Pharm. Adione, Nnamdi MarkBen Graduate Assistant B.Pharm, M.Pharm
14. Pharm. Ajah, Keziah Uchechi Graduate Assistant B.Pharm

 

 

LIST OF  TECHNICAL STAFF

S/N NAME OF STAFF PRESENT RANK  ACADEMIC QUALIFICATIONS  STAFF ID NO
1 Mrs. Anunobi Joy Amara Lab. Technologist I B.Sc

 

SS-2656
2 Mr. Ajawobu Innocent Oghale Lab. Technologist I OND

HND

PGD

SS-2694
3. Mr. Ufere Emele Njoku Lab. Technologist I ND

HND

SS- 2912
4. Ezenagu, Chioma Lucy Technologist II B.Sc SS 4641

 

LIST OF NON- ACADEMIC STAFF

LIST OF SENIOR NON- ACADEMIC STAFF

 

 

S/N

 

 

NAME OF STAFF

 

PRESENT RANK 

 

ACADEMIC QUALIFICATIONS 

 

STAFF ID NO

1. Mrs.  Nwajiobi Roseline  Nonye Senior Executive Officer OND JS 1569
2 Enyeribe Emilia Ugochi Admin Assistant B.Sc SS 4384

 

LIST OF LABORATORY ASSISTANT

S/N NAME OF STAFF PRESENT RANK  ACADEMIC QUALIFICATIONS  STAFF ID NO
1 Mr. Akabogu Victory Chukwudi Laboratory supervisor SSCE JS-2349