Medicinal Chemistry Programmes

DEPARTMENT OF PHARMACEUTICAL AND MEDICINAL CHEMISTRY

A)  FULL-TIME BACHELOR OF PHARMACY (B.PHARM) PROGRAMME.

Admission Requirements

Regular undergraduate students are admitted into the programme through University Matriculation Examination (UME), Direct Entry and JUPEB

Minimum of five (5) O’ LEVEL credits to include: English Language, Mathematics, Physics, Chemistry, Biology obtained in not more than two sittings.

B)MASTERS’ DEGREE

  1. MASTER OF PHARMACY DEGREE (M. Pharm)

The candidate must have a first degree with a FCGPA of not less than 3.0 in Pharmacy from Nnamdi Azikiwe University or a recognized University.

 

     2.MASTER OF SCIENCE (M. Sc)

The candidate must have a first degree with a FCGPA of not less than 3.0 in Chemistry or Biochemistry from Nnamdi Azikiwe University or a recognized University.

C)DOCTOR OF PHILOSOPHY (Ph.D) DEGREE

A candidate who holds a master’s degree in Pharmaceutical/Medicinal Chemistry, Pharmacognosy (Pharmaceutical Biology), Chemistry or Biochemistry with a FCGPA of not less than 3.50 on 5.0 scale or an average of 70 % from Nnamdi Azikiwe University or a recognized University may be admitted provided the University Matriculation requirement is satisfied.

AVAILABLE AREAS OF SPECIALIZATION

  • Drug synthesis and Combinatorial Chemistry
  • Medicinal Chemistry and Drug Design
  • Natural Products Medicinal Chemistry
  • Quality control and Analytical Pharmaceutical Chemistry

 

UNDERGRADUATE COURSES

1st Year, First Semester
Course CodeCourse TitleCredits
ICH101Basic Organic Chemistry2
ICH111Basic Inorganic Chemistry2
BIO101General Biology 12
PHY101General Physics 13
PHY103General Physics 1113
PHY107General Physics Lab 11
MAT101General mathematics 13
GSS 101Use of English 11
GSS 105Humanities2
GSS107Nigerian Peoples and Culture2
GSS108Basic Igbo Studies 11
CSCIntroduction to Computer Programming2

 

1st Year, Second Semester
Course CodeCourse TitleCredits
ICH102Basic Physical Chemistry2
ICH112Basic Practical Chemistry1
BIO102General Biology 113
BIO103General Practical Biology1
PHY102General Physics 113
PHY108General Physics Lab 111
MAT102General Mathematics 113
GSS102Use of English 111
GSS106Social Sciences2
GSS109Basic Igbo Studies 111
CSC102Introduction to Computer Programming 112
ZOO102Introduction to Zoology2

 

 

2nd Year, First Semester
Course CodeCourse TitleCredits
PCL201Introduction to Pharmacy Practice2
PTE203Pharmaceutical Calculations2
PMB205Introduction to Biochemistry3
PCO211Human Gross Anatomy/Neuroanatomy2
PCG221Introductory Pharmacognosy2
PCO213Introduction to Human Physiology 12
PCO215General Principles of Physiology2
PMC231General Pharmaceutical & inorganic chemistry2
PMB281Introductory Pharmaceutical Microbiology2
PCO217Practical Human Anatomy/Histology1
PMB283Practical Introductory Pharmaceutical Microbiology1

 

 

2nd Year, Second Semester
Course CodeCourse TitleCredits
PCO214Introduction to Human Physiology 112
PCG222Indigenous Medicinal Plants2
PMC232General Physical,Organic and Radio Chemistry3
PTE242Introduction to pharmaceutics3
PMB202Introductory Practical Biochemistry1
UMT100University Mandatory Information Technology Training0
PHM204Use of Library and Study Skills1
PCO212Human Genetic Anatomy/Histology2
PCG224Practical Pharmacognosy1
PMC234Practical Pharmaceutical Physical Chemistry1
PTE244Practical Pharmaceutics (Dispensing)1
ENT200Entrepreneurship education and new venture creation0

 

 

3rd Year, First Semester
Course CodeCourse TitleCredits
PCG321Natural Products3
PMC331Pharmaceutical Organic Chemistry3
PTE341Physical Pharmaceutics3
PCO351Principles of Pharmacology2
PCO353Pharmacology of GIT and Peripheral nervous systems2
PCL371Introducti0n to Pharmacy Administration & Management2
PMB381Antimicrobial Pharmaceutical Products2
PCG323Practical Pharmacognosy 111
PTE343Practical  Physical Pharmaceutics1
PMB383Practical Antimicrobial Agents evaluation1

 

3rd Year, Second Semester
Course CodeCourse TitleCredits
PMC332Pharmaceutical Specification and Standardization2
PTE342Unit Operations2
PCO352Pharmacology of Cardiovascular and central nervous system2
PCL362Pharmacokinetics and Biopharmaceutics2
PCL364Health Psychology2
PHM306Biostatistics and Research Methods in Pharmacy3
PMB382Sterile Products Technology3
PMC334Practical Pharm. Qualitative Analysis1
PCO354Practical Pharmacology 11
PTE344Practical Unit Operations & Dispense Systems1
PMB384Practical Sterile Products Technology1
ENT300Entrepreneurial Skills0

 

4th Year, First Semester
Course CodeCourse TitleCredits
PCG421Phytoevaluation and phytoanalysis2
PTE441Tblet & Capsule Technology2
PCO451Chemotherapy2
PCL461Pathology for Pharmacy Students2
PCL471Pharmacy Ethics & Jurisprudence3
PMC431Instrumental Methods in Pharmaceutical Analysis2
PMB481Evaluation of antimicrobial agents2
PMB483Advanced Practical antimicrobial agents Evaluation1
PCO453Practical Pharmacology 111
PMC433Practical Pharmaceutical Analysis 111
PMC435Practical Pharmaceutical Synthesis1
PTE443Practical Tablet and Capsule Technology1

 

4th Year, Second Semester
Course CodeCourse TitleCredits
PMC432Medicinal Chemistry3
PMB482Basic Pharmaceutical Biotechnology and immunology3
PMB484Practical Introductory Pharmaceutical Biotechnology1
PTE444Advanced Dispensing2
PCG422Practical Phytoevaluation and Phytoanalysis1
PCL462Introduction to Clinical and Public Health Pharmacy2
PCO452Pharmacology of Endocrine and Respiratory Systems2
PTE446Practical Advanced Dispensing1
PCL464Supply Chain Management of Pharmaceutical and other heallth commodities3
PHM472SIWES4

 

5th Year, First Semester
Course CodeCourse TitleCredits
PCL561Pathology & Pharmacotherapeutics3
PCG521Herbal,Complementary & Alternative Medicines2
PCO551Screening Methods in Pharmacology2
PTE541Novel Drug Delivery Sysems and Drug Stability3
PMC531Pharmaceutical Analysis and Good Laboratory Principles2
PCO553Toxicology2
PMB581Clinical Applications of Pharmaceutical Microbiology2
PCL563Clinical Pharmacokinetics & Clinical Safety Evaluations2
PCL571Pharmacy Administration and Management2

 

 

5th Year, Second Semester
Course CodeCourse TitleCredits
PCL562Drug information,Literature Evaluation & Communication Skills2
PCL564Clinical Pharmacy Clerkship4
PCL566Drug Administration & Patient Medical Assessment2
PMB582Pharmaceutical Biotechnology3
PMC532Medicinal Chemistry,Drug Design and Development3
PTE542Industrial Pharmacy and Process Validation2
PCO552Veterinary Pharmacy and Agrochemicals2
PHM592Research Project4

 

PG COURSE DISTRIBUTION  

  1. PMC 801 Research Techniques in Pharmaceutical and Medicinal Chemistry
aLiterature review of relevant pharmaceutical materials used in the preparations of organic compounds involving various named reactions; isolation and characterization of natural products e.g alkaloids, glycosides, flavonoids, essential oils etc.Dr. Mrs Blessing Umeokoli
bQualitative estimation of elements in organic compounds and quantitative estimation of various functional groups. Assay of selected drugs by official methods.Dr. F.A Onyegbule
cExperiments on electrophoresis, Chromatography, spectrophotometry, calorimetry and other relevant and current techniques.Dr. K.G Ngwoke
dProposal writing.

Overview of techniques in molecular visualization and modeling.

Prof. I.C Uzochukwu

 

  1. PMC 803 Advanced medicinal Chemistry
AA general study of the correlation of physical properties and chemical structure with biological activity. Stereochemistry and drug action.

Introduction to nanomedicinal chemistry: gold nanoparticles, carbon nanostructures, organic functionalization of carbon nanostructures and application in biomedicine

Prof. F.B.C Okoye
bStructure – activity relationship and mechanism of action of some important categories of drugs such as : tranquilizers, new steroidal drugs.Dr. K.G Ngwoke
cChemotherapy of neoplastic diseases, antiviral drugs

A critical review of drugs comprising racemic mixtures

Dr Mrs C.C Abba

 

 

  1. PMC 827: Computational Chemistry and Molecular Modeling
aWhat is Bioinformatics ? Glossary of terms  Overview of bioinformatics and applications: Drug discovery Chemoinformatics; An important scientific discipline Visualization of biomolecules using VMD, PyMol etc.

History of human genome project and important tropical pathogens such as plasmodium. Students should prepare an updated table of important genome projects. Definition of the ‘omics’, genome annotation, genome association studies. Pharmaceutical significance of bioinformatics. Examples of their application in pharmaceutical science. The hidden markov model, gene annotation, protein structure prediction, sequence analysis and alignment using TCoffe, DaliLite etc, evolutionary and phylogenetic analysis, algorithms in protein analysis. Mathematical modeling of drug design and interactions. Chemical formula file format. ADMET prediction tools. Other Chemoinformatic tools and approaches. Viral screening protocols.

Prof. I.C Uzochukwu
  1. PMC 811: Pharmaceutical Analysis and Quality Control
aThe study of chemical basis of product quality control and assurance. A detailed approach to the instrument and chemical analysis of raw materials employed in the production of pharmaceutical and cosmetics.Dr Mrs C.C Abba

 

bThe application of available analytical methods in establishing the quality of pharmaceuticals/cosmetics and mixtures thereof, especially of those products marketed in Nigeria. In vivo and in vitro correlation. Review on bioanalytical method validation. EMEA of analytical procedure.Prof. I.C Uzochukwu

 

  1. PMC 823: Advanced Drug Design
aA comprehensive study of the relevant factor in rational drug design. Drug receptor interactions. Drug discovery process. Hit identification, lead discovery. Quantitative structure activity relationships, 3D QSAR.Dr. K.G Ngwoke
bCustom design and synthesis of specific, pure, and desired drug molecules. Enzyme inhibition. Design of prodrugs. The Lipinski rule among other rules to predict drug-likeness. Blood brain barrier permeability etc. Approach and examples of drug repurposingProf. I.C Uzochukwu

 

  1. Advanced Organic Chemistry
aA detailed study of organic reaction mechanisms. Kinetics, electronic effects, polar free radical and pericyclic mechanisms. Stereochemistry; stereoselective synthesis. Study of important name reactions (including applications in drug synthesis)Prof. P.O Osadebe

 

bAdvanced mechanism of nucleophilic substitution reactions and factors affecting them. Elimination reaction; mechanisms and factor affecting them.

Organo-mettalic compounds, Grignard synthesis, organo-aluminium, organo-zink, organo-zink, organo-lithium compounds, preparation and uses.

Some specific organic reactions: Michael addition, Walden inversion, Woodward-Hoffmann-rule. Recent methods for forming Heterocyclic rings, Synthesis using intermediates.

Dr. Mrs Blessing Umeokoli
cSynthetic uses of free radicals: main types of free radicals reaction. Radical forming reactions, radical destroying processes, radical transfer processes. New reduction methods; electrochemical reduction; photochemical reduction. New oxidation methods; electrochemical oxidation, organic peroxide. Photochemical methods; photo addition reactions, photocyclization, rearrangement.Dr. F.A Onyegbule
dAromatic substitution reactions, new synthesis of aromatic compounds, ring synthesis, synthesis of reactive intermediates, functional groups, some specific organic reactions, 1,3-dipolar cyclo-addition reactions. Diel-adder synthesis. Photochemical ring closures, ring expansion reactions, miscellaneous ring synthesis. Green chemistry concept.Prof. F.B.C Okoye

 

    7. PMC 802: Modern Analytical Techniques

APrinciple of spectrophotometry and applications of absorption spectra (ultraviolet, visible, infrared), to structure elucidation and determination in pharmaceutical chemistry.

Atomic absorption spectroscopy, flame photometry, fluorescence.

Dr. Mrs Blessing Umeokoli
BThe use of nuclear magnetic resonance (1D and 2D, 1HNMR and 13C NMR), mass spectroscopy in confirmation of organic structures.Prof. F.B.C Okoye

 

CGas Liquid Chromatography (GLC), High Pressure Liquid Chromatography (HPLC), Hyphenated Techniques. Electrophoresis.Dr. K.G Ngwoke
DPolarimetry: X-ray diffraction analysis. A course of laboratory work in which the students are expected to make use of the following instrumental and chemical methods in analysis and quality control of chemicals and pharmaceuticals. Electrochemistry (mainly potentiometric titration and polarography).

Non aqueous titration; oxygen combusting flask, complexometric titration EDTA. Indicator extraction methods.

Dr. F.A Onyegbule

 

 

    8.PMC 806: Laboratory Instruction Orientations

AThis involves participation in the preparation and instruction of undergraduate practical in Pharmaceutical and Medicinal Chemistry Department as a teaching assistant followed by the submission of a written report in the form of log bookDepartmental PG Coordinator/HOD

 

    9.PMC 812: Toxicological Chemistry

AQualitative and quantitative analysis of various potent toxic drugs viz: barbiturate, opium, chlordiazepoxide, diazepamDr Mrs C.C Abba
BQualitative and quantitative analysis of various potent toxic drugs viz: acontrine, strychnine, methaqualone, glutethimide, deiphenylhydrazine, phenothizines.Dr. F.A Onyegbule

 

CSpecific analysis of heavy metals by atomic-absorption spectroscopy viz: arsenic, beryllium, bismuth, copper, iron, lead, lithium, mercury, nickel, tantalum and zinc.

Isolation of toxic compounds and their determination utilizing modern methods of analysis

Dr. K.G Ngwoke

 

 

 

  10.PMC 824: Drug synthesis and Combinatorial Chemistry

AIntroduction to combinatorial chemistry and drug synthesis. Case studies of several reactions affording drug molecules.Prof. F.B.C Okoye

 

BThe concept of green chemistry. Semi synthesis of drugs using typical examples such as artemisinin.Prof. I.C Uzochukwu

 

    11.PMC 826: Pharmocokinetics

AKinetics of absorption, distribution and elimination. Drug metabolism, mathematical treatment of the various pharmacokinetic processes; urinary, plasma/serum and salivary pharmacokinetics models.Dr Sunny Nduka

 

    12.PMC 828: Chemistry of Natural Product

AGeneral methods of isolation and purification of plant products. Study of biogenesis; acetate hypothesis, isoprene roles, biogenetic hypothesis relating to alkaloids.Dr. K.G Ngwoke
BThe chemistry and biosynthesis of natural products including alkaloids, flavonoids, steroids, terpenoids, tannins, glycosides, lipids, proteins, carbohydratesDr Mrs C.C Abba
CGeneral study of natural of natural products from microorganisms (including fungi endophyte) and marine organisms.

Application of NMR and mass spectrometry in structure elucidation of plants. Secondary metabolites viz: steroids, terpenes, alkaloids, flavonoid and flavonoid glycosides and other phenolic compounds.

Prof. F.B.C Okoye

 

 

    13.PMC 804: Applied Biostatistics

Biostatical definition: Variance, Standard deviation and Standard error. Normal distribution, Confidence limits.

Meaning and uses of statistics. Frequency distribution, sampling and sampling techniques, questionnaire design, measures of central tendency and measures of dispersion.

 

Probability and probability distribution; Estimation, Point and interval estimation. Test of hypothesis of hypothesis, regression and correlation, Chi-square, null hypothesis, T-Test, Analysis of variance, One way and two way ANOVA, Simple non-parametric tests, Latin square design, Randomized complex block design, Missing data, sub-sampling; Transformation; Analysis of clinical trials; Application; Fertility indicator and positive health indicator and index.

 

Pictorial presentation of data; pie chart, bar chart. Risk assessment, odd ratios etc. Study of various computer packages relevant in solving pharmaceutical and biomedical problems.

Dr Mrs Chinwe Uzuke

 

LIST OF ACADEMIC STAFF 

 

S/N

 

NAME OF STAFF

 

PRESENT RANK

 

ACADEMIC QUALIFICATIONS

 

STAFF ID NO

1.Dr. Abba Chika ChristianaSenior LecturerB.Sc, B.Pharm, M.Pharm

Ph.D

SS- 2731
2.Prof. Osadebe, Patience OgoamakaAdjunct ProfessorB.Pharm, M.Pharm, Ph.DSS-2233
3.Prof. Eboka Chukwuenwenive JonathanAdjunct ProfessorB.Sc, M.Sc, Ph.DSS-2749
4.Prof.  Uzochukwu Ikemefuna ChijiokeProfessorB. Pharm, M. Pharm

Ph.D

SS-1766
5Prof.  Okoye Festus Basden ChieduProfessorB. Pharm, M. Pharm

Ph.D

SS-2509
6.Dr. Onyegbule Ahamefule FelixReaderB.Sc, M.Sc, Ph.DSS-2152
7.Dr. Ngwoke Kenneth GeraldSenior LecturerB. Pharm, M. Sc, Ph.DSS -2683
8.Pharm Okafor Uche GabrielLecturer IB.pharm , M. PharmSS-1979
9.Dr. Fortunatus C. EzebuoLecturer IIB.Sc  M.Sc Ph.DSS 4287
10.Anyanwu Ogechi OziomaLecturer IIB.Sc, M.ScSS  3725
11.Pharm. Okpoli, Innocent NchekwubeLecturer IIB.Pharm, M.Pharm
12.Pharm. Okolo, Chukwubuikem ChinaezeLecturer IIB.Pharm, M.Pharm
13Pharm. Adione, Nnamdi MarkBenGraduate AssistantB.Pharm, M.Pharm
14.Pharm. Ajah, Keziah UchechiGraduate AssistantB.Pharm

 

 

LIST OF  TECHNICAL STAFF

S/NNAME OF STAFFPRESENT RANK  ACADEMIC QUALIFICATIONS  STAFF ID NO
1Mrs. Anunobi Joy AmaraLab. Technologist IB.Sc

 

SS-2656
2Mr. Ajawobu Innocent OghaleLab. Technologist IOND

HND

PGD

SS-2694
3.Mr. Ufere Emele NjokuLab. Technologist IND

HND

SS- 2912
4.Ezenagu, Chioma LucyTechnologist IIB.ScSS 4641

 

LIST OF NON- ACADEMIC STAFF

LIST OF SENIOR NON- ACADEMIC STAFF

 

 

S/N

 

 

NAME OF STAFF

 

PRESENT RANK 

 

ACADEMIC QUALIFICATIONS 

 

STAFF ID NO

1.Mrs.  Nwajiobi Roseline  NonyeSenior Executive OfficerONDJS 1569
2Enyeribe Emilia UgochiAdmin AssistantB.ScSS 4384

 

LIST OF LABORATORY ASSISTANT

S/NNAME OF STAFFPRESENT RANK  ACADEMIC QUALIFICATIONS  STAFF ID NO
1Mr. Akabogu Victory ChukwudiLaboratory supervisorSSCEJS-2349