DEPARTMENT OF PHARMACEUTICAL AND MEDICINAL CHEMISTRY
A) FULL-TIME BACHELOR OF PHARMACY (B.PHARM) PROGRAMME.
Admission Requirements
Regular undergraduate students are admitted into the programme through University Matriculation Examination (UME), Direct Entry and JUPEB
Minimum of five (5) O’ LEVEL credits to include: English Language, Mathematics, Physics, Chemistry, Biology obtained in not more than two sittings.
B)MASTERS’ DEGREE
- MASTER OF PHARMACY DEGREE (M. Pharm)
The candidate must have a first degree with a FCGPA of not less than 3.0 in Pharmacy from Nnamdi Azikiwe University or a recognized University.
2.MASTER OF SCIENCE (M. Sc)
The candidate must have a first degree with a FCGPA of not less than 3.0 in Chemistry or Biochemistry from Nnamdi Azikiwe University or a recognized University.
C)DOCTOR OF PHILOSOPHY (Ph.D) DEGREE
A candidate who holds a master’s degree in Pharmaceutical/Medicinal Chemistry, Pharmacognosy (Pharmaceutical Biology), Chemistry or Biochemistry with a FCGPA of not less than 3.50 on 5.0 scale or an average of 70 % from Nnamdi Azikiwe University or a recognized University may be admitted provided the University Matriculation requirement is satisfied.
AVAILABLE AREAS OF SPECIALIZATION
- Drug synthesis and Combinatorial Chemistry
- Medicinal Chemistry and Drug Design
- Natural Products Medicinal Chemistry
- Quality control and Analytical Pharmaceutical Chemistry
UNDERGRADUATE COURSES
| 1st Year, First Semester | ||
| Course Code | Course Title | Credits |
| ICH101 | Basic Organic Chemistry | 2 |
| ICH111 | Basic Inorganic Chemistry | 2 |
| BIO101 | General Biology 1 | 2 |
| PHY101 | General Physics 1 | 3 |
| PHY103 | General Physics 111 | 3 |
| PHY107 | General Physics Lab 1 | 1 |
| MAT101 | General mathematics 1 | 3 |
| GSS 101 | Use of English 1 | 1 |
| GSS 105 | Humanities | 2 |
| GSS107 | Nigerian Peoples and Culture | 2 |
| GSS108 | Basic Igbo Studies 1 | 1 |
| CSC | Introduction to Computer Programming | 2 |
| 1st Year, Second Semester | ||
| Course Code | Course Title | Credits |
| ICH102 | Basic Physical Chemistry | 2 |
| ICH112 | Basic Practical Chemistry | 1 |
| BIO102 | General Biology 11 | 3 |
| BIO103 | General Practical Biology | 1 |
| PHY102 | General Physics 11 | 3 |
| PHY108 | General Physics Lab 11 | 1 |
| MAT102 | General Mathematics 11 | 3 |
| GSS102 | Use of English 11 | 1 |
| GSS106 | Social Sciences | 2 |
| GSS109 | Basic Igbo Studies 11 | 1 |
| CSC102 | Introduction to Computer Programming 11 | 2 |
| ZOO102 | Introduction to Zoology | 2 |
| 2nd Year, First Semester | ||
| Course Code | Course Title | Credits |
| PCL201 | Introduction to Pharmacy Practice | 2 |
| PTE203 | Pharmaceutical Calculations | 2 |
| PMB205 | Introduction to Biochemistry | 3 |
| PCO211 | Human Gross Anatomy/Neuroanatomy | 2 |
| PCG221 | Introductory Pharmacognosy | 2 |
| PCO213 | Introduction to Human Physiology 1 | 2 |
| PCO215 | General Principles of Physiology | 2 |
| PMC231 | General Pharmaceutical & inorganic chemistry | 2 |
| PMB281 | Introductory Pharmaceutical Microbiology | 2 |
| PCO217 | Practical Human Anatomy/Histology | 1 |
| PMB283 | Practical Introductory Pharmaceutical Microbiology | 1 |
| 2nd Year, Second Semester | ||
| Course Code | Course Title | Credits |
| PCO214 | Introduction to Human Physiology 11 | 2 |
| PCG222 | Indigenous Medicinal Plants | 2 |
| PMC232 | General Physical,Organic and Radio Chemistry | 3 |
| PTE242 | Introduction to pharmaceutics | 3 |
| PMB202 | Introductory Practical Biochemistry | 1 |
| UMT100 | University Mandatory Information Technology Training | 0 |
| PHM204 | Use of Library and Study Skills | 1 |
| PCO212 | Human Genetic Anatomy/Histology | 2 |
| PCG224 | Practical Pharmacognosy | 1 |
| PMC234 | Practical Pharmaceutical Physical Chemistry | 1 |
| PTE244 | Practical Pharmaceutics (Dispensing) | 1 |
| ENT200 | Entrepreneurship education and new venture creation | 0 |
| 3rd Year, First Semester | ||
| Course Code | Course Title | Credits |
| PCG321 | Natural Products | 3 |
| PMC331 | Pharmaceutical Organic Chemistry | 3 |
| PTE341 | Physical Pharmaceutics | 3 |
| PCO351 | Principles of Pharmacology | 2 |
| PCO353 | Pharmacology of GIT and Peripheral nervous systems | 2 |
| PCL371 | Introducti0n to Pharmacy Administration & Management | 2 |
| PMB381 | Antimicrobial Pharmaceutical Products | 2 |
| PCG323 | Practical Pharmacognosy 11 | 1 |
| PTE343 | Practical Physical Pharmaceutics | 1 |
| PMB383 | Practical Antimicrobial Agents evaluation | 1 |
| 3rd Year, Second Semester | ||
| Course Code | Course Title | Credits |
| PMC332 | Pharmaceutical Specification and Standardization | 2 |
| PTE342 | Unit Operations | 2 |
| PCO352 | Pharmacology of Cardiovascular and central nervous system | 2 |
| PCL362 | Pharmacokinetics and Biopharmaceutics | 2 |
| PCL364 | Health Psychology | 2 |
| PHM306 | Biostatistics and Research Methods in Pharmacy | 3 |
| PMB382 | Sterile Products Technology | 3 |
| PMC334 | Practical Pharm. Qualitative Analysis | 1 |
| PCO354 | Practical Pharmacology 1 | 1 |
| PTE344 | Practical Unit Operations & Dispense Systems | 1 |
| PMB384 | Practical Sterile Products Technology | 1 |
| ENT300 | Entrepreneurial Skills | 0 |
| 4th Year, First Semester | ||
| Course Code | Course Title | Credits |
| PCG421 | Phytoevaluation and phytoanalysis | 2 |
| PTE441 | Tblet & Capsule Technology | 2 |
| PCO451 | Chemotherapy | 2 |
| PCL461 | Pathology for Pharmacy Students | 2 |
| PCL471 | Pharmacy Ethics & Jurisprudence | 3 |
| PMC431 | Instrumental Methods in Pharmaceutical Analysis | 2 |
| PMB481 | Evaluation of antimicrobial agents | 2 |
| PMB483 | Advanced Practical antimicrobial agents Evaluation | 1 |
| PCO453 | Practical Pharmacology 11 | 1 |
| PMC433 | Practical Pharmaceutical Analysis 11 | 1 |
| PMC435 | Practical Pharmaceutical Synthesis | 1 |
| PTE443 | Practical Tablet and Capsule Technology | 1 |
| 4th Year, Second Semester | ||
| Course Code | Course Title | Credits |
| PMC432 | Medicinal Chemistry | 3 |
| PMB482 | Basic Pharmaceutical Biotechnology and immunology | 3 |
| PMB484 | Practical Introductory Pharmaceutical Biotechnology | 1 |
| PTE444 | Advanced Dispensing | 2 |
| PCG422 | Practical Phytoevaluation and Phytoanalysis | 1 |
| PCL462 | Introduction to Clinical and Public Health Pharmacy | 2 |
| PCO452 | Pharmacology of Endocrine and Respiratory Systems | 2 |
| PTE446 | Practical Advanced Dispensing | 1 |
| PCL464 | Supply Chain Management of Pharmaceutical and other heallth commodities | 3 |
| PHM472 | SIWES | 4 |
| 5th Year, First Semester | ||
| Course Code | Course Title | Credits |
| PCL561 | Pathology & Pharmacotherapeutics | 3 |
| PCG521 | Herbal,Complementary & Alternative Medicines | 2 |
| PCO551 | Screening Methods in Pharmacology | 2 |
| PTE541 | Novel Drug Delivery Sysems and Drug Stability | 3 |
| PMC531 | Pharmaceutical Analysis and Good Laboratory Principles | 2 |
| PCO553 | Toxicology | 2 |
| PMB581 | Clinical Applications of Pharmaceutical Microbiology | 2 |
| PCL563 | Clinical Pharmacokinetics & Clinical Safety Evaluations | 2 |
| PCL571 | Pharmacy Administration and Management | 2 |
| 5th Year, Second Semester | ||
| Course Code | Course Title | Credits |
| PCL562 | Drug information,Literature Evaluation & Communication Skills | 2 |
| PCL564 | Clinical Pharmacy Clerkship | 4 |
| PCL566 | Drug Administration & Patient Medical Assessment | 2 |
| PMB582 | Pharmaceutical Biotechnology | 3 |
| PMC532 | Medicinal Chemistry,Drug Design and Development | 3 |
| PTE542 | Industrial Pharmacy and Process Validation | 2 |
| PCO552 | Veterinary Pharmacy and Agrochemicals | 2 |
| PHM592 | Research Project | 4 |
PG COURSE DISTRIBUTION
- PMC 801 Research Techniques in Pharmaceutical and Medicinal Chemistry
| a | Literature review of relevant pharmaceutical materials used in the preparations of organic compounds involving various named reactions; isolation and characterization of natural products e.g alkaloids, glycosides, flavonoids, essential oils etc. | Dr. Mrs Blessing Umeokoli |
| b | Qualitative estimation of elements in organic compounds and quantitative estimation of various functional groups. Assay of selected drugs by official methods. | Dr. F.A Onyegbule |
| c | Experiments on electrophoresis, Chromatography, spectrophotometry, calorimetry and other relevant and current techniques. | Dr. K.G Ngwoke |
| d | Proposal writing.
Overview of techniques in molecular visualization and modeling. |
Prof. I.C Uzochukwu |
- PMC 803 Advanced medicinal Chemistry
| A | A general study of the correlation of physical properties and chemical structure with biological activity. Stereochemistry and drug action.
Introduction to nanomedicinal chemistry: gold nanoparticles, carbon nanostructures, organic functionalization of carbon nanostructures and application in biomedicine |
Prof. F.B.C Okoye |
| b | Structure – activity relationship and mechanism of action of some important categories of drugs such as : tranquilizers, new steroidal drugs. | Dr. K.G Ngwoke |
| c | Chemotherapy of neoplastic diseases, antiviral drugs
A critical review of drugs comprising racemic mixtures |
Dr Mrs C.C Abba
|
- PMC 827: Computational Chemistry and Molecular Modeling
| a | What is Bioinformatics ? Glossary of terms Overview of bioinformatics and applications: Drug discovery Chemoinformatics; An important scientific discipline Visualization of biomolecules using VMD, PyMol etc.
History of human genome project and important tropical pathogens such as plasmodium. Students should prepare an updated table of important genome projects. Definition of the ‘omics’, genome annotation, genome association studies. Pharmaceutical significance of bioinformatics. Examples of their application in pharmaceutical science. The hidden markov model, gene annotation, protein structure prediction, sequence analysis and alignment using TCoffe, DaliLite etc, evolutionary and phylogenetic analysis, algorithms in protein analysis. Mathematical modeling of drug design and interactions. Chemical formula file format. ADMET prediction tools. Other Chemoinformatic tools and approaches. Viral screening protocols. |
Prof. I.C Uzochukwu |
- PMC 811: Pharmaceutical Analysis and Quality Control
| a | The study of chemical basis of product quality control and assurance. A detailed approach to the instrument and chemical analysis of raw materials employed in the production of pharmaceutical and cosmetics. | Dr Mrs C.C Abba
|
| b | The application of available analytical methods in establishing the quality of pharmaceuticals/cosmetics and mixtures thereof, especially of those products marketed in Nigeria. In vivo and in vitro correlation. Review on bioanalytical method validation. EMEA of analytical procedure. | Prof. I.C Uzochukwu |
- PMC 823: Advanced Drug Design
| a | A comprehensive study of the relevant factor in rational drug design. Drug receptor interactions. Drug discovery process. Hit identification, lead discovery. Quantitative structure activity relationships, 3D QSAR. | Dr. K.G Ngwoke |
| b | Custom design and synthesis of specific, pure, and desired drug molecules. Enzyme inhibition. Design of prodrugs. The Lipinski rule among other rules to predict drug-likeness. Blood brain barrier permeability etc. Approach and examples of drug repurposing | Prof. I.C Uzochukwu |
- Advanced Organic Chemistry
| a | A detailed study of organic reaction mechanisms. Kinetics, electronic effects, polar free radical and pericyclic mechanisms. Stereochemistry; stereoselective synthesis. Study of important name reactions (including applications in drug synthesis) | Prof. P.O Osadebe
|
| b | Advanced mechanism of nucleophilic substitution reactions and factors affecting them. Elimination reaction; mechanisms and factor affecting them.
Organo-mettalic compounds, Grignard synthesis, organo-aluminium, organo-zink, organo-zink, organo-lithium compounds, preparation and uses. Some specific organic reactions: Michael addition, Walden inversion, Woodward-Hoffmann-rule. Recent methods for forming Heterocyclic rings, Synthesis using intermediates. |
Dr. Mrs Blessing Umeokoli |
| c | Synthetic uses of free radicals: main types of free radicals reaction. Radical forming reactions, radical destroying processes, radical transfer processes. New reduction methods; electrochemical reduction; photochemical reduction. New oxidation methods; electrochemical oxidation, organic peroxide. Photochemical methods; photo addition reactions, photocyclization, rearrangement. | Dr. F.A Onyegbule |
| d | Aromatic substitution reactions, new synthesis of aromatic compounds, ring synthesis, synthesis of reactive intermediates, functional groups, some specific organic reactions, 1,3-dipolar cyclo-addition reactions. Diel-adder synthesis. Photochemical ring closures, ring expansion reactions, miscellaneous ring synthesis. Green chemistry concept. | Prof. F.B.C Okoye |
7. PMC 802: Modern Analytical Techniques
| A | Principle of spectrophotometry and applications of absorption spectra (ultraviolet, visible, infrared), to structure elucidation and determination in pharmaceutical chemistry.
Atomic absorption spectroscopy, flame photometry, fluorescence. |
Dr. Mrs Blessing Umeokoli |
| B | The use of nuclear magnetic resonance (1D and 2D, 1HNMR and 13C NMR), mass spectroscopy in confirmation of organic structures. | Prof. F.B.C Okoye
|
| C | Gas Liquid Chromatography (GLC), High Pressure Liquid Chromatography (HPLC), Hyphenated Techniques. Electrophoresis. | Dr. K.G Ngwoke |
| D | Polarimetry: X-ray diffraction analysis. A course of laboratory work in which the students are expected to make use of the following instrumental and chemical methods in analysis and quality control of chemicals and pharmaceuticals. Electrochemistry (mainly potentiometric titration and polarography).
Non aqueous titration; oxygen combusting flask, complexometric titration EDTA. Indicator extraction methods. |
Dr. F.A Onyegbule
|
8.PMC 806: Laboratory Instruction Orientations
| A | This involves participation in the preparation and instruction of undergraduate practical in Pharmaceutical and Medicinal Chemistry Department as a teaching assistant followed by the submission of a written report in the form of log book | Departmental PG Coordinator/HOD |
9.PMC 812: Toxicological Chemistry
| A | Qualitative and quantitative analysis of various potent toxic drugs viz: barbiturate, opium, chlordiazepoxide, diazepam | Dr Mrs C.C Abba |
| B | Qualitative and quantitative analysis of various potent toxic drugs viz: acontrine, strychnine, methaqualone, glutethimide, deiphenylhydrazine, phenothizines. | Dr. F.A Onyegbule
|
| C | Specific analysis of heavy metals by atomic-absorption spectroscopy viz: arsenic, beryllium, bismuth, copper, iron, lead, lithium, mercury, nickel, tantalum and zinc.
Isolation of toxic compounds and their determination utilizing modern methods of analysis |
Dr. K.G Ngwoke |
10.PMC 824: Drug synthesis and Combinatorial Chemistry
| A | Introduction to combinatorial chemistry and drug synthesis. Case studies of several reactions affording drug molecules. | Prof. F.B.C Okoye
|
| B | The concept of green chemistry. Semi synthesis of drugs using typical examples such as artemisinin. | Prof. I.C Uzochukwu |
11.PMC 826: Pharmocokinetics
| A | Kinetics of absorption, distribution and elimination. Drug metabolism, mathematical treatment of the various pharmacokinetic processes; urinary, plasma/serum and salivary pharmacokinetics models. | Dr Sunny Nduka |
12.PMC 828: Chemistry of Natural Product
| A | General methods of isolation and purification of plant products. Study of biogenesis; acetate hypothesis, isoprene roles, biogenetic hypothesis relating to alkaloids. | Dr. K.G Ngwoke |
| B | The chemistry and biosynthesis of natural products including alkaloids, flavonoids, steroids, terpenoids, tannins, glycosides, lipids, proteins, carbohydrates | Dr Mrs C.C Abba |
| C | General study of natural of natural products from microorganisms (including fungi endophyte) and marine organisms.
Application of NMR and mass spectrometry in structure elucidation of plants. Secondary metabolites viz: steroids, terpenes, alkaloids, flavonoid and flavonoid glycosides and other phenolic compounds. |
Prof. F.B.C Okoye
|
13.PMC 804: Applied Biostatistics
| Biostatical definition: Variance, Standard deviation and Standard error. Normal distribution, Confidence limits.
Meaning and uses of statistics. Frequency distribution, sampling and sampling techniques, questionnaire design, measures of central tendency and measures of dispersion.
Probability and probability distribution; Estimation, Point and interval estimation. Test of hypothesis of hypothesis, regression and correlation, Chi-square, null hypothesis, T-Test, Analysis of variance, One way and two way ANOVA, Simple non-parametric tests, Latin square design, Randomized complex block design, Missing data, sub-sampling; Transformation; Analysis of clinical trials; Application; Fertility indicator and positive health indicator and index.
Pictorial presentation of data; pie chart, bar chart. Risk assessment, odd ratios etc. Study of various computer packages relevant in solving pharmaceutical and biomedical problems. |
Dr Mrs Chinwe Uzuke |
LIST OF ACADEMIC STAFF
|
S/N |
NAME OF STAFF |
PRESENT RANK |
ACADEMIC QUALIFICATIONS |
STAFF ID NO |
| 1. | Dr. Abba Chika Christiana | Senior Lecturer | B.Sc, B.Pharm, M.Pharm
Ph.D |
SS- 2731 |
| 2. | Prof. Osadebe, Patience Ogoamaka | Adjunct Professor | B.Pharm, M.Pharm, Ph.D | SS-2233 |
| 3. | Prof. Eboka Chukwuenwenive Jonathan | Adjunct Professor | B.Sc, M.Sc, Ph.D | SS-2749 |
| 4. | Prof. Uzochukwu Ikemefuna Chijioke | Professor | B. Pharm, M. Pharm
Ph.D |
SS-1766 |
| 5 | Prof. Okoye Festus Basden Chiedu | Professor | B. Pharm, M. Pharm
Ph.D |
SS-2509 |
| 6. | Dr. Onyegbule Ahamefule Felix | Reader | B.Sc, M.Sc, Ph.D | SS-2152 |
| 7. | Dr. Ngwoke Kenneth Gerald | Senior Lecturer | B. Pharm, M. Sc, Ph.D | SS -2683 |
| 8. | Pharm Okafor Uche Gabriel | Lecturer I | B.pharm , M. Pharm | SS-1979 |
| 9. | Dr. Fortunatus C. Ezebuo | Lecturer II | B.Sc M.Sc Ph.D | SS 4287 |
| 10. | Anyanwu Ogechi Ozioma | Lecturer II | B.Sc, M.Sc | SS 3725 |
| 11. | Pharm. Okpoli, Innocent Nchekwube | Lecturer II | B.Pharm, M.Pharm | |
| 12. | Pharm. Okolo, Chukwubuikem Chinaeze | Lecturer II | B.Pharm, M.Pharm | |
| 13 | Pharm. Adione, Nnamdi MarkBen | Graduate Assistant | B.Pharm, M.Pharm | |
| 14. | Pharm. Ajah, Keziah Uchechi | Graduate Assistant | B.Pharm
|
LIST OF TECHNICAL STAFF
| S/N | NAME OF STAFF | PRESENT RANK | ACADEMIC QUALIFICATIONS | STAFF ID NO |
| 1 | Mrs. Anunobi Joy Amara | Lab. Technologist I | B.Sc
|
SS-2656 |
| 2 | Mr. Ajawobu Innocent Oghale | Lab. Technologist I | OND
HND PGD |
SS-2694 |
| 3. | Mr. Ufere Emele Njoku | Lab. Technologist I | ND
HND |
SS- 2912 |
| 4. | Ezenagu, Chioma Lucy | Technologist II | B.Sc | SS 4641 |
LIST OF NON- ACADEMIC STAFF
LIST OF SENIOR NON- ACADEMIC STAFF
|
S/N |
NAME OF STAFF |
PRESENT RANK |
ACADEMIC QUALIFICATIONS |
STAFF ID NO |
|||
| 1. | Mrs. Nwajiobi Roseline Nonye | Senior Executive Officer | OND | JS 1569 | |||
| 2 | Enyeribe Emilia Ugochi | Admin Assistant | B.Sc | SS 4384 | |||
LIST OF LABORATORY ASSISTANT
| S/N | NAME OF STAFF | PRESENT RANK | ACADEMIC QUALIFICATIONS | STAFF ID NO |
| 1 | Mr. Akabogu Victory Chukwudi | Laboratory supervisor | SSCE | JS-2349 |